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Ultrasonic-assisted unusual four-component synthesis of 7-azolylamino-4,5,6,7-tetrahydroazolo[1,5-a]pyrimidines.

ABSTRACT: Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1H-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-a]pyrimidines.

SUBMITTER: Sakhno YI

PROVIDER: S-EPMC7059450 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Ultrasonic-assisted unusual four-component synthesis of 7-azolylamino-4,5,6,7-tetrahydroazolo[1,5-a]pyrimidines.

Sakhno Yana I YI Murlykina Maryna V MV Zbruyev Oleksandr I OI Kozyryev Anton V AV Shishkina Svetlana V SV Sysoiev Dmytro D Musatov Vladimir I VI Desenko Sergey M SM Chebanov Valentyn A VA

Beilstein journal of organic chemistry 20200227

Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1H-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-a]pyrimidines. ...[more]

PMID: 32180844

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