Ontology highlight
ABSTRACT:
SUBMITTER: Paladin L
PROVIDER: S-EPMC7059794 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20170701 W1
Solubility is an important, albeit not well understood, feature determining protein behavior. It is of paramount importance in protein engineering, where similar folded proteins may behave in very different ways in solution. Here we present SODA, a novel method to predict the changes of protein solubility based on several physico-chemical properties of the protein. SODA uses the propensity of the protein sequence to aggregate as well as intrinsic disorder, plus hydrophobicity and secondary struc ...[more]