NDRG1 activates VEGF-A-induced angiogenesis through PLC?1/ERK signaling in mouse vascular endothelial cells.
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ABSTRACT:
SUBMITTER: Watari K
PROVIDER: S-EPMC7060337 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells.
Watari Kosuke K Shibata Tomohiro T Fujita Hideaki H Shinoda Ai A Murakami Yuichi Y Abe Hideyuki H Kawahara Akihiko A Ito Hiroshi H Akiba Jun J Yoshida Shigeo S Kuwano Michihiko M Ono Mayumi M
Communications biology 20200306 1
Many diseases, including cancer, have been associated with impaired regulation of angiogenesis, of which vascular endothelial growth factor (VEGF)-A is a key regulator. Here, we test the contribution of N-myc downstream regulated gene 1 (NDRG1) to VEGF-A-induced angiogenesis in vascular endothelial cells (ECs). Ndrg1<sup>-/-</sup> mice exhibit impaired VEGF-A-induced angiogenesis in corneas. Tumor angiogenesis induced by cancer cells that express high levels of VEGF-A was also reduced in a mouse ...[more]
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