Genome-wide analysis of constitutional DNA methylation in familial melanoma.
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ABSTRACT:
SUBMITTER: Salgado C
PROVIDER: S-EPMC7060565 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Genome-wide analysis of constitutional DNA methylation in familial melanoma.
Salgado Catarina C Gruis Nelleke N Heijmans Bastiaan T BT Oosting Jan J van Doorn Remco R
Clinical epigenetics 20200306 1
<h4>Background</h4>Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathogenic variants in established melanoma susceptibility genes, compared with healthy volunteers.<h4>Results</h4>All melanoma susceptibility genes showed the absence of epimutations in familial melanoma patients, and no loss of imprinting was detected. Unbiased genome-wide DNA ...[more]
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