Ontology highlight
ABSTRACT:
SUBMITTER: Hyland PL
PROVIDER: S-EPMC4063827 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Hyland Paula L PL Burke Laura S LS Pfeiffer Ruth M RM Rotunno Melissa M Sun David D Patil Prasad P Wu Xiaolin X Tucker Margaret A MA Goldstein Alisa M AM Yang Xiaohong Rose XR
Epigenetics 20140213 5
Constitutional epigenetic changes detected in blood or non-disease involving tissues have been associated with disease susceptibility. We measured promoter methylation of CDKN2A (p16 and p14ARF) and 13 melanoma-related genes using bisulfite pyrosequencing of blood DNA from 114 cases and 122 controls in 64 melanoma-prone families (26 segregating CDKN2A germline mutations). We also obtained gene expression data for these genes using microarrays from the same blood samples. We observed that CDKN2A ...[more]