Concordance of Lumipulse cerebrospinal fluid t-tau/A?42 ratio with amyloid PET status.

ABSTRACT:

Introduction

Cerebrospinal fluid (CSF) biomarkers can identify individuals with Alzheimer's disease (AD) pathology (eg, amyloid plaques, neurofibrillary tangles), but defined analyte cut-points using high-throughput automated assays are necessary for general clinical use.

Methods

CSF amyloid ?42 peptide (A?42), t-tau, and t-tau/A?42 were quantified by the Lumipulse platform in two test cohorts (A/B: Eisai BAN2401-201/MISSION AD E2609-301/302, n = 138; C: Knight Alzheimer's Disease Research Center (ADRC), n = 198), and receiver operating characteristic (ROC) curve analyses defined cut-points corresponding best to amyloid determinations using positron emission tomography (PET) imaging. The best-performing cut-point was then validated as a predictor of amyloid status in an independent cohort (D: MISSION AD E2609-301/302, n = 240).

Results

Virtually identical t-tau/A?42 cut-points (?0.54) performed best in both test cohorts and with similar accuracy (areas under ROC curve [AUCs] [A/B: 0.95; C: 0.94]). The cut-point yielded an overall percent agreement with amyloid PET of 85.0% in validation cohort D.

Discussion

Lumipulse CSF biomarker measures with validated cut-points have clinical utility in identifying AD pathology.

SUBMITTER: Kaplow J 

PROVIDER: S-EPMC7061432 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature