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A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/A?42 cutoff with concordance to amyloid positron emission tomography imaging.


ABSTRACT: INTRODUCTION:Changes in cerebrospinal fluid (CSF) tau and amyloid ? (A?)42 accompany development of Alzheimer's brain pathology. Robust tau and A?42 immunoassays were developed to establish a tau/A?42 cutoff distinguishing mild-to-moderate Alzheimer's disease (AD) subjects from healthy elderly control (HC) subjects. METHODS:A CSF tau/A?42 cutoff criteria was chosen, which distinguished the groups and maximized concordance with amyloid PET. Performance was assessed using an independent validation cohort. RESULTS:A tau/A?42 = 0.215 cutoff provided 94.8% sensitivity and 77.7% specificity. Concordance with PET visual reads was estimated at 86.9% in a ?50% PET positive population. In the validation cohort, the cutoff demonstrated 78.4% sensitivity and 84.9% specificity to distinguish the AD and HC populations. DISCUSSION:A tau/A?42 cutoff with acceptable sensitivity and specificity distinguished HC from mild-to-moderate AD subjects and maximized concordance to brain amyloidosis. The defined cutoff demonstrated that CSF analysis may be useful as a surrogate to imaging assessment of AD pathology.

SUBMITTER: Mo Y 

PROVIDER: S-EPMC5357677 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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<h4>Introduction</h4>Changes in cerebrospinal fluid (CSF) tau and amyloid β (Aβ)42 accompany development of Alzheimer's brain pathology. Robust tau and Aβ42 immunoassays were developed to establish a tau/Aβ42 cutoff distinguishing mild-to-moderate Alzheimer's disease (AD) subjects from healthy elderly control (HC) subjects.<h4>Methods</h4>A CSF tau/Aβ42 cutoff criteria was chosen, which distinguished the groups and maximized concordance with amyloid PET. Performance was assessed using an indepen  ...[more]

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