Ontology highlight
ABSTRACT:
SUBMITTER: Mo Y
PROVIDER: S-EPMC5357677 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Mo Yi Y Stromswold Julie J Wilson Kimberly K Holder Daniel D Sur Cyrille C Laterza Omar O Savage Mary J MJ Struyk Arie A Scheltens Philip P Teunissen Charlotte E CE Burke James J Macaulay S Lance SL Bråthen Geir G Sando Sigrid Botne SB White Linda R LR Weiss Christy C Cowes Arturo A Bush Michele M MM DeSilva Ganga G Darby David G DG Rainey-Smith Stephanie R SR Surls Jackie J Sagini Eileen E Tanen Michael M Altman Amy A Luthman Johan J Egan Michael F MF
Alzheimer's & dementia (Amsterdam, Netherlands) 20170306
<h4>Introduction</h4>Changes in cerebrospinal fluid (CSF) tau and amyloid β (Aβ)42 accompany development of Alzheimer's brain pathology. Robust tau and Aβ42 immunoassays were developed to establish a tau/Aβ42 cutoff distinguishing mild-to-moderate Alzheimer's disease (AD) subjects from healthy elderly control (HC) subjects.<h4>Methods</h4>A CSF tau/Aβ42 cutoff criteria was chosen, which distinguished the groups and maximized concordance with amyloid PET. Performance was assessed using an indepen ...[more]