Electrospun thymosin Beta-4 loaded PLGA/PLA nanofiber/ microfiber hybrid yarns for tendon tissue engineering application.
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ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC7061461 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Electrospun thymosin Beta-4 loaded PLGA/PLA nanofiber/ microfiber hybrid yarns for tendon tissue engineering application.
Wu Shaohua S Zhou Rong R Zhou Fang F Streubel Philipp N PN Chen Shaojuan S Duan Bin B
Materials science & engineering. C, Materials for biological applications 20191012
Microfiber yarns (MY) have been widely employed to construct tendon tissue grafts. However, suboptimal ultrastructure and inappropriate environments for cell interactions limit their clinical application. Herein, we designed a modified electrospinning device to coat poly(lactic-co-glycolic acid) PLGA nanofibers onto polylactic acid (PLA) MY to generate PLGA/PLA hybrid yarns (HY), which had a well-aligned nanofibrous structure, resembling the ultrastructure of native tendon tissues and showed enh ...[more]
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