Ontology highlight
ABSTRACT:
SUBMITTER: Wu F
PROVIDER: S-EPMC7062719 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200309 1
Glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that plays an important role in glucose homeostasis and treatment of type 2 diabetes. Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism. Here, we report the 3.2 Å resolution ...[more]