Ontology highlight
ABSTRACT:
SUBMITTER: Doi N
PROVIDER: S-EPMC3254644 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Doi Nobuhide N Yamakawa Natsuko N Matsumoto Hideaki H Yamamoto Yasutsugu Y Nagano Tetsuya T Matsumura Nobutaka N Horisawa Kenichi K Yanagawa Hiroshi H
PloS one 20120110 1
The G protein-coupled receptors (GPCRs), which form the largest group of transmembrane proteins involved in signal transduction, are major targets of currently available drugs. Thus, the search for cognate and surrogate peptide ligands for GPCRs is of both basic and therapeutic interest. Here we describe the application of an in vitro DNA display technology to screening libraries of peptide ligands for full-length GPCRs expressed on whole cells. We used human angiotensin II (Ang II) type-1 recep ...[more]