Ontology highlight
ABSTRACT:
SUBMITTER: Schorer M
PROVIDER: S-EPMC7062903 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Schorer Michelle M Rakebrandt Nikolas N Lambert Katharina K Hunziker Annika A Pallmer Katharina K Oxenius Annette A Kipar Anja A Stertz Silke S Joller Nicole N
Nature communications 20200309 1
Co-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and restricting immune pathology. The TIGIT pathway has been implicated in promoting T cell dysfunction in chronic viral infection. Importantly, TIGIT signaling is functionally linked to IL-10 expression, which has an effect on both virus control and maintenance of tissue homeostasis. However, whether TIGIT has a function in viral persistence or ...[more]