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The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target.

ABSTRACT: The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke.

SUBMITTER: Tian Y

PROVIDER: S-EPMC7063119 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target.

Tian Yanjun Y Chen Ruijiao R Jiang Yunlu Y Bai Bo B Yang Tongju T Liu Haiqing H

Frontiers in neurology 20200303

The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic strok ...[more]

PMID: 32194492

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Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system.

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Modulation of the apelin/APJ system in heart failure and atherosclerosis in man.

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