Ontology highlight
ABSTRACT:
SUBMITTER: Howard MK
PROVIDER: S-EPMC7064214 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Howard Matthew K MK Sohn Brian S BS von Borcke Julius J Xu Andy A Jackrel Meredith E ME
PloS one 20200310 3
Hsp104 is a hexameric AAA+ yeast disaggregase capable of solubilizing disordered aggregates and amyloid. Hsp104 couples ATP hydrolysis to polypeptide translocation through its central channel. Substrate binding by Hsp104 is mediated primarily by two conserved tyrosine residues in nucleotide binding domain (NBD) 1 and NBD2. Recent structural studies have revealed that an additional tyrosine residue (Y650) located in NBD2 appears to contact substrate and may play an important role in Hsp104 functi ...[more]