Ontology highlight
ABSTRACT:
SUBMITTER: Fraley AE
PROVIDER: S-EPMC7065246 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Fraley Amy E AE Caddell Haatveit Kersti K Ye Ying Y Kelly Samantha P SP Newmister Sean A SA Yu Fengan F Williams Robert M RM Smith Janet L JL Houk K N KN Sherman David H DH
Journal of the American Chemical Society 20200116 5
The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds. One key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional architecture to these structures. The flavin monooxygenase PhqK was found to catalyze spirocycle formation through two parallel pathways in the biosynthesis of paraherquamides A and G. Two new paraherquamides (K and L) were isolated from a Δ<i>phqK</i> strain of <i>Penicillium simplicissimum</i>, a ...[more]