Ontology highlight
ABSTRACT:
SUBMITTER: Kato HE
PROVIDER: S-EPMC7065593 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Kato Hideaki E HE Zhang Yan Y Hu Hongli H Suomivuori Carl-Mikael CM Kadji Francois Marie Ngako FMN Aoki Junken J Krishna Kumar Kaavya K Fonseca Rasmus R Hilger Daniel D Huang Weijiao W Latorraca Naomi R NR Inoue Asuka A Dror Ron O RO Kobilka Brian K BK Skiniotis Georgios G
Nature 20190626 7767
Neurotensin receptor 1 (NTSR1) is a G-protein-coupled receptor (GPCR) that engages multiple subtypes of G protein, and is involved in the regulation of blood pressure, body temperature, weight and the response to pain. Here we present structures of human NTSR1 in complex with the agonist JMV449 and the heterotrimeric G<sub>i1</sub> protein, at a resolution of 3 Å. We identify two conformations: a canonical-state complex that is similar to recently reported GPCR-G<sub>i/o</sub> complexes (in whic ...[more]