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Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis.

ABSTRACT: Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.

SUBMITTER: Maczynska E

PROVIDER: S-EPMC7065616 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis.

Maczynska Ewa E Karnowski Karol K Szulzycki Krzysztof K Malinowska Monika M Dolezyczek Hubert H Cichanski Artur A Wojtkowski Maciej M Kaluzny Bartlomiej B Grulkowski Ireneusz I

Journal of biophotonics 20181014 2

Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of ...[more]

PMID: 30239154

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Project description:ObjectiveTo validate a new method for reconstructing corneal biomechanical properties from air puff corneal deformation images using hydrogel polymer model corneas and porcine corneas.MethodsAir puff deformation imaging was performed on model eyes with artificial corneas made out of three different hydrogel materials with three different thicknesses and on porcine eyes, at constant intraocular pressure of 15 mmHg. The cornea air puff deformation was modeled using finite elements, and hyperelastic material parameters were determined through inverse modeling, minimizing the difference between the simulated and the measured central deformation amplitude and central-peripheral deformation ratio parameters. Uniaxial tensile tests were performed on the model cornea materials as well as on corneal strips, and the results were compared to stress-strain simulations assuming the reconstructed material parameters.ResultsThe measured and simulated spatial and temporal profiles of the air puff deformation tests were in good agreement (< 7% average discrepancy). The simulated stress-strain curves of the studied hydrogel corneal materials fitted well the experimental stress-strain curves from uniaxial extensiometry, particularly in the 0-0.4 range. Equivalent Young´s moduli of the reconstructed material properties from air-puff were 0.31, 0.58 and 0.48 MPa for the three polymer materials respectively which differed < 1% from those obtained from extensiometry. The simulations of the same material but different thickness resulted in similar reconstructed material properties. The air-puff reconstructed average equivalent Young´s modulus of the porcine corneas was 1.3 MPa, within 18% of that obtained from extensiometry.ConclusionsAir puff corneal deformation imaging with inverse finite element modeling can retrieve material properties of model hydrogel polymer corneas and real corneas, which are in good correspondence with those obtained from uniaxial extensiometry, suggesting that this is a promising technique to retrieve quantitative corneal biomechanical properties.

Dataset Information

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis.

Publications

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis.

Similar Datasets

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