Ontology highlight
ABSTRACT:
SUBMITTER: Dalaka E
PROVIDER: S-EPMC7065877 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Dalaka E E Kronenberg N M NM Liehm P P Segall J E JE Prystowsky M B MB Gather M C MC
Science advances 20200311 11
Mechanobiology plays a prominent role in cancer invasion and metastasis. The ability of a cancer to degrade extracellular matrix (ECM) is likely connected to its invasiveness. Many cancer cells form invadopodia-micrometer-sized cellular protrusions that promote invasion through matrix degradation (proteolysis). Although it has been hypothesized that invadopodia exert mechanical force that is implicated in cancer invasion, direct measurements remain elusive. Here, we use a recently developed inte ...[more]