Ontology highlight
ABSTRACT:
SUBMITTER: Khayyo VI
PROVIDER: S-EPMC7066176 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Khayyo Valerie I VI Hoffmann Reece M RM Wang Huan H Bell Justin A JA Burke John E JE Reue Karen K Airola Michael V MV
Nature communications 20200311 1
Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Inactivating mutations cause rhabdomyolysis, autoinflammatory disease, and aberrant fat storage. Disease-mutations cluster within the conserved N-Lip and C-Lip regions that are separated by 500-residues in humans. To understand how the N-Lip and C-Lip combine for PAP function, we determined crystal structures of Tetrahymena thermophila Pah2 (Tt Pah2) that directly fu ...[more]