Ontology highlight
ABSTRACT:
SUBMITTER: Smith-Geater C
PROVIDER: S-EPMC7066322 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Smith-Geater Charlene C Hernandez Sarah J SJ Lim Ryan G RG Adam Miriam M Wu Jie J Stocksdale Jennifer T JT Wassie Brook T BT Gold Maxwell Philip MP Wang Keona Q KQ Miramontes Ricardo R Kopan Lexi L Orellana Iliana I Joy Shona S Kemp Paul J PJ Allen Nicholas D ND Fraenkel Ernest E Thompson Leslie M LM
Stem cell reports 20200227 3
Aberrant neuronal development and the persistence of mitotic cellular populations have been implicated in a multitude of neurological disorders, including Huntington's disease (HD). However, the mechanism underlying this potential pathology remains unclear. We used a modified protocol to differentiate induced pluripotent stem cells (iPSCs) from HD patients and unaffected controls into neuronal cultures enriched for medium spiny neurons, the cell type most affected in HD. We performed single-cell ...[more]