Ontology highlight
ABSTRACT:
SUBMITTER: Haak AJ
PROVIDER: S-EPMC7066514 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Haak Andrew J AJ Kostallari Enis E Sicard Delphine D Ligresti Giovanni G Choi Kyoung Moo KM Caporarello Nunzia N Jones Dakota L DL Tan Qi Q Meridew Jeffrey J Diaz Espinosa Ana M AM Aravamudhan Aja A Maiers Jessica L JL Britt Rodney D RD Roden Anja C AC Pabelick Christina M CM Prakash Y S YS Nouraie Seyed Mehdi SM Li Xiaoyun X Zhang Yingze Y Zhang Yingze Y Kass Daniel J DJ Lagares David D Tager Andrew M AM Varelas Xaralabos X Shah Vijay H VH Tschumperlin Daniel J DJ
Science translational medicine 20191001 516
Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) have recently emerged as pivotal drivers of mesenchymal cell activation in human fibrosis. Therapeutic strategies inhibiting YAP and TAZ have been hindered by the critical role that these proteins play in regeneration and homeostasis in different c ...[more]