Dataset Information

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.

ABSTRACT: In this population-based prospective study, we examined the association of job demand-control combinations with dementia, and explored the roles of Apolipoprotein E epsilon4 (APOE ?4) and work duration in this association. A total of 2,579 dementia-free individuals aged 60+ years from Sweden were followed over 12 years. Dementia diagnosis was made by physicians. Lifelong occupational experience was collected, and job demands and control were assessed using a psychosocial job-exposure matrix. Data were analyzed using multivariate Cox proportional hazard models. During the follow-up, 282 people developed dementia. Passive jobs (low control/low demands) were related to a higher risk of dementia compared with active jobs (high control/high demands) among the younger-old (aged ?72 years), but not among the older-old (aged ?78 years). Among the younger-old, compared to those with no passive job experience, those with 11+ years in passive jobs had a higher dementia risk. The joint-effect analyses showed that APOE ?4 carriers with passive jobs had an even higher risk of dementia compared to APOE ?4 non-carriers with active jobs. These findings suggest that passive jobs are related to a higher dementia risk among the younger-old. APOE ?4 and long work duration may amplify the impact of passive jobs on dementia.

SUBMITTER: Pan KY

PROVIDER: S-EPMC7066897 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.

Pan Kuan-Yu KY Xu Weili W Mangialasche Francesca F Grande Giulia G Fratiglioni Laura L Wang Hui-Xin HX

Aging 20200220 4

In this population-based prospective study, we examined the association of job demand-control combinations with dementia, and explored the roles of Apolipoprotein E epsilon4 (<i>APOE</i> ɛ4) and work duration in this association. A total of 2,579 dementia-free individuals aged 60+ years from Sweden were followed over 12 years. Dementia diagnosis was made by physicians. Lifelong occupational experience was collected, and job demands and control were assessed using a psychosocial job-exposure matr ...[more]

PMID: 32081835

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Project description:BackgroundCognitive complaints involving problems with concentration, memory, decision-making and thinking are relatively common in the work force. The sensitivity of both subjective and objective cognitive functioning to common psychiatric conditions, stress levels and to cognitive load makes it plausible that psychosocial working conditions play a role in cognitive complaints. Thus, this study aimed to test the associations between psychosocial work factors and cognitive complaints in nationally representative samples of the Swedish work force. Cross-sectional (n?=?9751) and prospective (n?=?3644; two time points two years apart) sequential multiple regression analyses were run, adjusting for general confounders, depressive- and sleeping problems. Additional prospective analyses were run adjusting for baseline cognitive complaints.Cross/sectional resultsHigh quantitative demands, information and communication technology (ICT) demands, under qualification and conflicts were positively associated with cognitive complaints, while social support, good resources at work and over qualification were negatively associated with cognitive complaints in all models. Skill discretion and decision authority were weakly associated with cognitive complaints. Conflicts were more strongly associated with cognitive complaints in women than in men, after adjustment for general confounders.Prospective resultsQuantitative job demands, ICT demands and under qualification were positively associated with future cognitive complaints in all models, including when adjusted for baseline cognitive complaints. Decision authority was weakly positively associated with future cognitive complaints, only after adjustment for depressive- and sleeping problems respectively. Social support was negatively associated with future cognitive complaints after adjustment for general confounders and baseline cognitive complaints. Skill discretion and resources were negatively associated with future cognitive complaints after adjustment for general confounders. The associations between quantitative demands and future cognitive complaints were stronger in women.Discussion/conclusionsThe findings indicate that psychosocial working conditions should be taken into account when considering cognitive complaints among employees.

Dataset Information

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.

Publications

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia.

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