Ontology highlight
ABSTRACT:
SUBMITTER: Bravi B
PROVIDER: S-EPMC7067494 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Bravi Barbara B Ravasio Riccardo R Brito Carolina C Wyart Matthieu M
PLoS computational biology 20200302 3
In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable interest in inferring them from sequence alignment data. Currently, different methods lead to conflicting results, in particular on the existence of long-range evolutionary couplings between distant amino-acids mediating allostery. Here we propose a resolution of this conundrum, by studying epistasis and its inference ...[more]