Ontology highlight
ABSTRACT:
SUBMITTER: Yip MCJ
PROVIDER: S-EPMC7067598 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yip Matthew C J MCJ Savickas Simonas S Gygi Steven P SP Shao Sichen S
Cell reports 20200201 7
Ribosome-associated quality control (RQC) disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. A key step of RQC is the cleavage of P-site tRNA by the endonuclease ANKZF1 (Vms1 in yeast) to release incompletely synthesized polypeptides from ribosomes for degradation. Re-use of the cleaved tRNA for translation requires re-addition of the universal 3'CCA nucleotides removed by ANKZF1. Here, we show that ELAC1 is both necessary and sufficient to remove ...[more]