Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga.

ABSTRACT: BACKGROUND:44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga (0.83 MeV) can result in better spatial image resolutions. However, high-energy γ-rays (1157 keV) are emitted at high rates (99.9%) during 44Sc decay, which can reduce image quality. Therefore, we investigated the impact of these physical properties and performed an unbiased performance evaluation of 44Sc and 68Ga with different imaging phantoms (image quality phantom, Derenzo phantom, and three-rod phantom) on two preclinical PET scanners (Mediso nanoScan PET/MRI, Siemens microPET Focus 120). RESULTS:Despite the presence of high-energy γ-rays in 44Sc decay, a higher ima

SUBMITTER: Rosar F 

PROVIDER: S-EPMC7067939 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature