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Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis.


ABSTRACT: BACKGROUND:Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to ABA in patients with RA. METHODS:Peripheral blood was collected using a PAX gene Blood RNA kit from 45 bDMARD-naïve patients with RA at baseline and at 6?months after the initiation of ABA treatment. Gene expression levels of responders (n?=?27) and non-responders (n?=?8) to ABA treatment among patients with RA at baseline were compared using a microarray. The gene expression levels were confirmed using real-time quantitative polymerase chain reaction (RT-qPCR). RESULTS:Gene expression analysis revealed that the expression levels of 218 genes were significantly higher and those of 392 genes were significantly lower in the responders compared to the non-responders. Gene ontology analysis of the 218 genes identified "response to type I interferon (IFN)" with 24 type I IFN-related genes. RT-qPCR confirmed that there was a strong correlation between the score calculated using the 24 genes and that using OAS3, MX1, and IFIT3 (type I IFN score) (rho with the type I IFN score 0.981); the type I IFN score was significantly decreased after treatment with ABA in the responders (p?

SUBMITTER: Yokoyama-Kokuryo W 

PROVIDER: S-EPMC7068901 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis.

Yokoyama-Kokuryo Waka W   Yamazaki Hayato H   Takeuchi Tsutomu T   Amano Koichi K   Kikuchi Jun J   Kondo Tsuneo T   Nakamura Seiji S   Sakai Ryoko R   Hirano Fumio F   Nanki Toshihiro T   Koike Ryuji R   Harigai Masayoshi M  

Arthritis research & therapy 20200312 1


<h4>Background</h4>Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to ABA in patients with RA.<h4>Methods</h4>Peripheral blood was collected using a PAX gene Blood RNA kit from 45 bDMARD-naïve patients with RA at baseline and at 6 months after the initiation of ABA treatment. Gene expression levels of responders (n = 27) and non-responders (n  ...[more]

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