A Computational Approach for Mapping Heme Biology in the Context of Hemolytic Disorders.

ABSTRACT: Heme is an iron ion-containing molecule found within hemoproteins such as hemoglobin and cytochromes that participates in diverse biological processes. Although excessive heme has been implicated in several diseases including malaria, sepsis, ischemia-reperfusion, and disseminated intravascular coagulation, little is known about its regulatory and signaling functions. Furthermore, the limited understanding of heme's role in regulatory and signaling functions is in part due to the lack of curated pathway resources for heme cell biology. Here, we present two resources aimed to exploit this unexplored information to model heme biology. The first resource is a terminology covering heme-specific terms not yet included in standard controlled vocabularies. Using this terminology, we curated and m

SUBMITTER: Humayun F 

PROVIDER: S-EPMC7069124 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature