Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC7070065 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Wang Guan G Kang Xi X Chen Katherine S KS Jehng Tiffany T Jones Lindsey L Chen Jie J Huang Xue F XF Chen Si-Yi SY
Nature communications 20200313 1
Oncolytic viruses offer an in situ vaccination approach to activate tumor-specific T cell responses. However, the upregulation of PD-L1 expression on tumor cells and immune cells leads to tumor resistance to oncolytic immunotherapy. In this study, we generate an engineered oncolytic virus that coexpresses a PD-L1 inhibitor and GM-CSF. We find that the oncolytic virus is able to secrete the PD-L1 inhibitor that systemically binds and inhibits PD-L1 on tumor cells and immune cells. Importantly, th ...[more]