Dataset Information

Effects of Thymol and Thymol ?-D-Glucopyranoside on Intestinal Function and Microbiota of Weaned Pigs.

ABSTRACT: The present study evaluated gluco-conjugation as a measure to delay thymol absorption and enhance its antimicrobial activity in the gut of weaned piglets. The three dietary treatments consisted of a basal diet without additives (TCON), supplemented with thymol at 3.7 mmol/kg dry matter (TTHY), or with an equimolar amount of thymol ?-D-glucopyranoside (TT?G). Each dietary treatment was replicated in 6 pens with 2 piglets per pen (n = 12 for analytical parameters) and was supplemented for 14 days. The total (free plus gluco-conjugated) thymol concentrations in the stomach contents were 14% lower in TT?G as compared to TTHY piglets. Neither of the additives could be detected further down the gut. E.coli counts in the proximal small intestine were significantly lower in TTHY than in TT?G pigs (3.35 vs. 4.29 log10 CFU/g); however, other bacterial counts and their metabolites were unaffected by treatment. A metagenomic bacterial analysis revealed a great relative abundance of Lactobacillus spp. in the distal small intestine (range 88.4%-99.9%), irrespective of treatment. The intestinal barrier function was improved by TTHY, but not TT?G, compared to TCON. In conclusion, gluco-conjugation did not result in higher thymol concentrations in the gut, but conversely, it seemed to diminish the biological effects of thymol in vivo.

SUBMITTER: Van Noten N

PROVIDER: S-EPMC7070699 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Effects of Thymol and Thymol α-D-Glucopyranoside on Intestinal Function and Microbiota of Weaned Pigs.

Van Noten Noémie N Degroote Jeroen J Van Liefferinge Elout E Taminiau Bernard B De Smet Stefaan S Desmet Tom T Michiels Joris J

Animals : an open access journal from MDPI 20200219 2

The present study evaluated gluco-conjugation as a measure to delay thymol absorption and enhance its antimicrobial activity in the gut of weaned piglets. The three dietary treatments consisted of a basal diet without additives (TCON), supplemented with thymol at 3.7 mmol/kg dry matter (TTHY), or with an equimolar amount of thymol α-D-glucopyranoside (TTαG). Each dietary treatment was replicated in 6 pens with 2 piglets per pen (n = 12 for analytical param ...[more]

PMID: 32092931

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Dataset Information

Effects of Thymol and Thymol ?-D-Glucopyranoside on Intestinal Function and Microbiota of Weaned Pigs.

Publications

Effects of Thymol and Thymol α-D-Glucopyranoside on Intestinal Function and Microbiota of Weaned Pigs.

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