Ontology highlight
ABSTRACT:
SUBMITTER: Pan S
PROVIDER: S-EPMC7070790 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Pan Shan S Tsakok Teresa T Dand Nick N Lonsdale Dagan O DO Loeff Floris C FC Bloem Karien K de Vries Annick A Baudry David D Duckworth Michael M Mahil Satveer S Pushpa-Rajah Angela A Russell Alice A Alsharqi Ali A Becher Gabrielle G Murphy Ruth R Wahie Shyamal S Wright Andrew A Griffiths Christopher E M CEM Reynolds Nick J NJ Barker Jonathan J Warren Richard B RB David Burden A A Rispens Theo T Standing Joseph F JF Smith Catherine H CH
Clinical and translational science 20200129 2
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line therapeutic antibody ustekinumab. The impact of differing dosing strategies on response was explored. Data were collected from a UK prospective multicenter observational cohort (491 patients on ustekinumab monotherapy, drug levels, and anti-drug anti ...[more]