Ontology highlight
ABSTRACT:
SUBMITTER: Nardin JM
PROVIDER: S-EPMC7070802 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nardin Jeanine Marie JM Schroth Werner W Almeida Thais Abreu TA Mürdter Thomas T Picolotto Solane S Vendramini Evelyn Castillo Lima ECL Hoppe Reiner R Kogin Jenifer Primon JP Miqueleto Diandra D de Moraes Silvia Dark Robaskievicz SDR Schwab Matthias M Pecoits-Filho Roberto Flavio RF Brauch Hiltrud H Casali-da-Rocha José Claudio JC
Clinical and translational science 20191109 2
Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)-endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6, and 12 months of treatment (liquid-chromatography tandem mass spectrometry), adherence behavior (Morisky, Green, and Levine medication adherence scale), and cytochrome P450 2D6 (CYP2D6) and other phar ...[more]