Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
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ABSTRACT:
SUBMITTER: Antognelli C
PROVIDER: S-EPMC7071005 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
Antognelli Cinzia C Perrelli Andrea A Armeni Tatiana T Nicola Talesa Vincenzo V Retta Saverio Francesco SF
Antioxidants (Basel, Switzerland) 20200201 2
Dicarbonyl stress is a dysfunctional state consisting in the abnormal accumulation of reactive α-oxaldehydes leading to increased protein modification. In cells, post-translational changes can also occur through S-glutathionylation, a highly conserved oxidative post-translational modification consisting of the formation of a mixed disulfide between glutathione and a protein cysteine residue. This review recapitulates the main findings supporting a role for dicarbonyl stress and S-glutathionylati ...[more]
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