Ontology highlight
ABSTRACT:
SUBMITTER: Benninghoff AD
PROVIDER: S-EPMC7071445 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Benninghoff Abby D AD Hintze Korry J KJ Monsanto Stephany P SP Rodriguez Daphne M DM Hunter Ashli H AH Phatak Sumira S Pestka James J JJ Wettere Arnaud J Van AJV Ward Robert E RE
Nutrients 20200220 2
Consumption of a Western type diet is a known risk factor for colorectal cancer. Our group previously developed the total Western diet (TWD) for rodents with energy and nutrient profiles that emulate a typical Western diet. In this study, we tested the hypothesis that consumption of the TWD would enhance colitis, delay recovery from gut injury and promote colon tumorigenesis. In multiple experiments using the azoxymethane + dextran sodium sulfate or <i>Apc<sup>Min/+</sup></i> mouse models of col ...[more]