Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation.
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ABSTRACT:
SUBMITTER: De Santis S
PROVIDER: S-EPMC7215554 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Winnie-<i>APC<sup>Min/+</sup></i> Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation.
De Santis Stefania S Verna Giulio G Serino Grazia G Armentano Raffaele R Cavalcanti Elisabetta E Liso Marina M Dicarlo Manuela M Coletta Sergio S Mastronardi Mauro M Lippolis Antonio A Tafaro Angela A Santino Angelo A Pinto Aldo A Campiglia Pietro P Huang Alex Y AY Cominelli Fabio F Pizarro Theresa T TT Chieppa Marcello M
International journal of molecular sciences 20200423 8
(1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with <i>Apc<sup>Min/+</sup></i> mice. (3) Results: The resulting Winnie-<i>Apc<sup>Min/+</sup></i> model combines an inflammatory background with ...[more]
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