A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer's disease.

ABSTRACT: BACKGROUND:Studies suggest a role of the innate immune system, including the activity of neutrophils, in neurodegeneration related to Alzheimer's disease (AD), but prospective cognitive data remain lacking in humans. We aimed to investigate the predictive relationship between neutrophil-associated inflammatory proteins in peripheral blood and changes in memory and executive function over 1?year in patients with AD. METHODS:Participants with AD were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neutrophil gelatinase-associated lipocalin (NGAL), myeloperoxidase (MPO), interleukin-8 (IL-8), macrophage inflammatory protein-1 beta (MIP-1?), and tumor necrosis factor (TNF) were assayed by luminex immunofluorescence multiplex assay at baseline. Confirmatory factor analysis was used to test an underlying neutrophil associated plasma inflammatory factor. Composite z-scores for memory and executive function were generated from multiple tests at baseline and at 1?year. A multiple linear regression model was used to investigate the association of the baseline inflammatory factor with changes in memory and executive function over 1?year. RESULTS:Among AD patients (n?=?109, age?=?74.8?±?8.1, 42% women, Mini Mental State Examination [MMSE]?=?23.6?±?1.9), the neutrophil-related inflammatory proteins NGAL (??=?0.595, p?

SUBMITTER: Bawa KK 

PROVIDER: S-EPMC7071641 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature