New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma.

ABSTRACT: BACKGROUND:Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these infections by phagocytosis and killing of pathogens. Analysis of neutrophil function used to be laborious and was therefore not applicable in routine diagnostics. Hence, we developed a quick and point-of-care method to assess a critical part of neutrophil function, neutrophil phagosomal acidification. The aim of this study was to investigate whether this method was able to analyze neutrophil functionality in severely injured patients and whether a relation with the development of infectious complications was present. RESULTS:Fifteen severely injured patients (median ISS of 3

SUBMITTER: Hesselink L 

PROVIDER: S-EPMC7072076 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature