Ontology highlight
ABSTRACT:
SUBMITTER: Benesch MGK
PROVIDER: S-EPMC7072337 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Benesch Matthew G K MGK Tang Xiaoyun X Brindley David N DN
Cancers 20200206 2
After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor, GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the intervening time, a deeper understanding of the role of the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis in breast cancer progression and treatment resistance has emerged. Concordantly, appreciation of the tumor microenvironment and chronic inflammation in cancer biology has matured. The role ...[more]