Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?
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ABSTRACT:
SUBMITTER: Wojcicki AV
PROVIDER: S-EPMC7072462 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?
Wojcicki Anna V AV Kadapakkam Meena M Frymoyer Adam A Lacayo Norman N Chae Hee-Don HD Sakamoto Kathleen M KM
Cancers 20200213 2
Acute myeloid leukemia (AML) is a clinically and genetically heterogenous malignancy of myeloid progenitor cells that affects patients of all ages. Despite decades of research and improvement in overall outcomes, standard therapy remains ineffective for certain subtypes of AML. Current treatment is intensive and leads to a number of secondary effects with varying results by patient population. Due to the high cost of discovery and an unmet need for new targeted therapies that are well tolerated, ...[more]
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