IL-33/IL-31 Axis in Osteoporosis.
Ontology highlight
ABSTRACT:
SUBMITTER: De Martinis M
PROVIDER: S-EPMC7072890 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
IL-33/IL-31 Axis in Osteoporosis.
De Martinis Massimo M Sirufo Maria Maddalena MM Suppa Mariano M Ginaldi Lia L
International journal of molecular sciences 20200213 4
The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. Here we focus on two newly discovered Th2 cytokines, IL-31 and IL-33, whose implications in osteoporosis are recently emerging. Clinical and experimental observations suggest an important role of the IL ...[more]
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