Ontology highlight
ABSTRACT:
SUBMITTER: Watson GM
PROVIDER: S-EPMC7073000 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200217 4
Grb7 is a signalling adapter protein that engages activated receptor tyrosine kinases at cellular membranes to effect downstream pathways of cell migration, proliferation and survival. Grb7's cellular location was shown to be regulated by the small calcium binding protein calmodulin (CaM). While evidence for a Grb7/CaM interaction is compelling, a direct interaction between CaM and purified Grb7 has not been demonstrated and quantitated. In this study we sought to determine this, and prepared pu ...[more]