Ontology highlight
ABSTRACT:
SUBMITTER: Wu N
PROVIDER: S-EPMC1783800 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Wu Nan N Hanson Susan M SM Francis Derek J DJ Vishnivetskiy Sergey A SA Thibonnier Marc M Klug Candice S CS Shoham Menachem M Gurevich Vsevolod V VV
Journal of molecular biology 20061003 5
Arrestins serve as multi-functional regulators of G-protein coupled receptors, interacting with hundreds of different receptor subtypes and a variety of other signaling proteins. Here we identify calmodulin as a novel arrestin interaction partner using three independent methods in vitro and in cells. Arrestin preferentially binds calcium-loaded calmodulin with a Kd value of approximately 7 microM, which is within range of endogenous calmodulin concentrations. The calmodulin binding site is local ...[more]