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ABSTRACT:
SUBMITTER: Alvarez Secord A
PROVIDER: S-EPMC7073274 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Alvarez Secord Angeles A Bell Burdett Kirsten K Owzar Kouros K Tritchler David D Sibley Alexander B AB Liu Yingmiao Y Starr Mark D MD Brady J Chris JC Lankes Heather A HA Hurwitz Herbert I HI Mannel Robert S RS Tewari Krishnansu S KS O'Malley David M DM Gray Heidi H Bakkum-Gamez Jamie N JN Fujiwara Keiichi K Boente Matthew M Deng Wei W Burger Robert A RA Birrer Michael J MJ Nixon Andrew B AB
Clinical cancer research : an official journal of the American Association for Cancer Research 20200109 6
<h4>Purpose</h4>GOG-0218, a double-blind placebo-controlled phase III trial, compared carboplatin and paclitaxel with placebo, bevacizumab followed by placebo, or bevacizumab followed by bevacizumab in advanced epithelial ovarian cancer (EOC). Results demonstrated significantly improved progression-free survival (PFS), but no overall survival (OS) benefit with bevacizumab. Blood samples were collected for biomarker analyses.<h4>Experimental design</h4>Plasma samples were analyzed via multiplex E ...[more]