Ontology highlight
ABSTRACT:
SUBMITTER: Buskes MJ
PROVIDER: S-EPMC7073886 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Buskes Melissa J MJ Clements Monica M Bachovchin Kelly A KA Jalani Hitesh B HB Leonard Allison A Bag Seema S Klug Dana M DM Singh Baljinder B Campbell Robert F RF Sciotti Richard J RJ El-Sakkary Nelly N Caffrey Conor R CR Pollastri Michael P MP Ferrins Lori L
ACS medicinal chemistry letters 20200110 3
We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm parasite, <i>Schistosoma mansoni</i>. This study reports the identification and preliminary development of several potently bioactive compounds against adult schistosomes, one or more of which represent promising leads f ...[more]