Ontology highlight
ABSTRACT:
SUBMITTER: Berroyer A
PROVIDER: S-EPMC7073998 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Berroyer Alexandra A Kim Nayun N
Genes 20200212 2
Topoisomerase I in eukaryotic cells is an important regulator of DNA topology. Its catalytic function is to remove positive or negative superhelical tension by binding to duplex DNA, creating a reversible single-strand break, and finally religating the broken strand. Proper maintenance of DNA topological homeostasis, in turn, is critically important in the regulation of replication, transcription, DNA repair, and other processes of DNA metabolism. One of the cellular processes regulated by the D ...[more]