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Synthesis and Antimicrobial Evaluation of Side-Chain Derivatives based on Eurotiumide A.


ABSTRACT: Side-chain derivatives of eurotiumide A, a dihydroisochroman-type natural product, have been synthesized and their antimicrobial activities described. Sixteen derivatives were synthesized from a key intermediate of the total synthesis of eurotiumide A, and their antimicrobial activities against two Gram-positive bacteria, methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA), and a Gram-negative bacterium, Porphyromonas gingivalis, were evaluated. The results showed that derivatives having an iodine atom on their aromatic ring instead of the prenyl moiety displayed better antimicrobial activity than eurotiumide A against MSSA and P. gingivalis. Moreover, we discovered that a derivative with an isopentyl side chain, which is a hydrogenated product of eurotiumide A, is the strongest antimicrobial agent against all three strains, including MRSA.

SUBMITTER: Nakayama A 

PROVIDER: S-EPMC7074549 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Synthesis and Antimicrobial Evaluation of Side-Chain Derivatives based on Eurotiumide A.

Nakayama Atsushi A   Sato Hideo H   Nakamura Tenta T   Hamada Mai M   Nagano Shuji S   Kameyama Shuhei S   Furue Yui Y   Hayashi Naoki N   Kamoshida Go G   Karanjit Sangita S   Oda Masataka M   Namba Kosuke K  

Marine drugs 20200130 2


Side-chain derivatives of eurotiumide A, a dihydroisochroman-type natural product, have been synthesized and their antimicrobial activities described. Sixteen derivatives were synthesized from a key intermediate of the total synthesis of eurotiumide A, and their antimicrobial activities against two Gram-positive bacteria, methicillin-susceptible and methicillin-resistant <i>Staphylococcus aureus</i> (MSSA and MRSA), and a Gram-negative bacterium, <i>Porphyromonas gingivalis</i>, were evaluated.  ...[more]

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