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Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.

ABSTRACT: A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.

SUBMITTER: Zhang X

PROVIDER: S-EPMC7927313 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.

Zhang Xing X Khalidi Omar O Kim So Young SY Wang Ruitong R Schultz Victor V Cress Brady F BF Gross Richard A RA Koffas Mattheos A G MAG Linhardt Robert J RJ

Bioorganic & medicinal chemistry letters 20160504 13

A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This ...[more]

PMID: 27210435

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