Ontology highlight
ABSTRACT:
SUBMITTER: Fray MA
PROVIDER: S-EPMC7075049 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Fray Michael A MA Charpentier John C JC Sylvain Nicholas R NR Seminario Maria-Cristina MC Bunnell Stephen C SC
Journal of cell science 20200313 5
Vav family guanine nucleotide exchange factors (GEFs) are essential regulators of immune function. Despite their structural similarity, Vav1 promotes and Vav2 opposes T cell receptor (TCR)-induced Ca<sup>2+</sup> entry. By using a Vav1-deficient Jurkat T cell line, we find that Vav1 facilitates Ca<sup>2+</sup> entry via non-catalytic scaffolding functions that are encoded by the catalytic core of Vav1 and flanking linker regions. We implicate, in this scaffolding function, a previously undescrib ...[more]