Unknown

Dataset Information

0

Circulating microRNA 134 sheds light on the diagnosis of major depressive disorder.


ABSTRACT: Major depressive disorder (MDD) is a prevalent and debilitating psychiatric mood disorder that lacks objective laboratory-based tests to support its diagnosis. A class of microRNAs (miRNAs) has been found to be centrally involved in regulating many molecular processes fundamental to central nervous system function. Among these miRNAs, miRNA-134 (miR-134) has been reported to be related to neurogenesis and synaptic plasticity. In this study, the hypothesis that plasma miR-134 can be used to diagnose MDD was tested. Perturbation of peripheral and central miR-134 in a depressive-like rat model was also examined. By reverse-transcription quantitative PCR, miR-134 was comparatively measured in a small set of plasma samples from MDD and healthy control (HC) subjects. To determine its diagnostic efficacy, plasma miR-134 levels were assessed in 100 MDD, 50 bipolar disorder (BD), 50 schizophrenic (SCZ), and 100 HC subjects. A chronic unpredictable mild stress (CUMS) rat model was also developed to evaluate miR-134 expression in plasma, hippocampus (HIP), prefrontal cortex (PFC), and olfactory bulb. We found that plasma miR-134 was significantly downregulated in MDD subjects. Diagnostically, plasma miR-134 levels could effectively distinguish MDD from HC with 79% sensitivity and 84% specificity, while distinguishing MDD from HC, BD, and SCZ subjects with 79% sensitivity and 76.5% specificity. Congruent with these clinical findings, CUMS significantly reduced miR-134 levels in the rat plasma, HIP, and PFC. Although limited by the relatively small sample size, these results demonstrated that plasma miR-134 displays potential ability as a biomarker for MDD.

SUBMITTER: Zhang HP 

PROVIDER: S-EPMC7075934 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Circulating microRNA 134 sheds light on the diagnosis of major depressive disorder.

Zhang Han-Ping HP   Liu Xiao-Lei XL   Chen Jian-Jun JJ   Cheng Ke K   Bai Shun-Jie SJ   Zheng Peng P   Zhou Chan-Juan CJ   Wang Wei W   Wang Hai-Yang HY   Zhong Lian-Mei LM   Xie Peng P  

Translational psychiatry 20200316 1


Major depressive disorder (MDD) is a prevalent and debilitating psychiatric mood disorder that lacks objective laboratory-based tests to support its diagnosis. A class of microRNAs (miRNAs) has been found to be centrally involved in regulating many molecular processes fundamental to central nervous system function. Among these miRNAs, miRNA-134 (miR-134) has been reported to be related to neurogenesis and synaptic plasticity. In this study, the hypothesis that plasma miR-134 can be used to diagn  ...[more]

Similar Datasets

| S-EPMC7476934 | biostudies-literature
| S-EPMC10436517 | biostudies-literature
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
2011-10-05 | GSE19738 | GEO
2012-04-27 | E-GEOD-37579 | biostudies-arrayexpress
2022-05-20 | PXD028947 | Pride
2010-10-17 | E-GEOD-24095 | biostudies-arrayexpress
2010-10-17 | GSE24095 | GEO
| S-EPMC3984890 | biostudies-literature
2014-01-21 | E-GEOD-54222 | biostudies-arrayexpress