Ontology highlight
ABSTRACT:
SUBMITTER: Tom EC
PROVIDER: S-EPMC7076251 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20200316 7
Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an oncoprotein in many solid tumors. Cell surface display of EGFR is essential for cellular responses to its ligands. While postactivation endocytic trafficking of EGFR has been well elucidated, little is known about mechanisms of basal/preactivation surface display of EGFR. Here, we identify a novel role of the endocytic regulator EHD1 and a potential EHD1 partner, RUSC2, in cell surface display of EGFR. EHD1 an ...[more]