Ontology highlight
ABSTRACT:
SUBMITTER: Elbezanti W
PROVIDER: S-EPMC7077212 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Elbezanti Weam W Lin Angel A Schirling Alexis A Jackson Alexandria A Marshall Matthew M Duyne Rachel Van RV Maldarelli Frank F Sardo Luca L Klase Zachary Z
Viruses 20200209 2
Antiretroviral therapy (ART) lowers human immunodeficiency virus type 1 (HIV-1) viral load to undetectable levels, but does not eliminate the latent reservoir. One of the factors controlling the latent reservoir is transcriptional silencing of the integrated HIV-1 long terminal repeat (LTR). The molecular mechanisms that control HIV-1 transcription are not completely understood. We have previously shown that RUNX1, a host transcription factor, may play a role in the establishment and maintenance ...[more]