Ontology highlight
ABSTRACT:
SUBMITTER: Nogimori T
PROVIDER: S-EPMC7077301 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nogimori Takuto T Ogami Koichi K Oishi Yuka Y Goda Ryoya R Hosoda Nao N Kitamura Yoshiaki Y Kitade Yukio Y Hoshino Shin-Ichi SI
Viruses 20200204 2
The 2'-5'-oligoadenylate synthetase (OAS)/RNase L system protects hosts against pathogenic viruses through cleavage of the exogenous single-stranded RNA. In this system, an evolutionally conserved RNA quality control factor Dom34 (known as Pelota (Pelo) in higher eukaryotes) forms a surveillance complex with RNase L to recognize and eliminate the exogenous RNA in a manner dependent on translation. Here, we newly identified that ATP-binding cassette sub-family E member 1 (ABCE1), which is also kn ...[more]